Automated Drug Infusion System Based on Fuzzy PID Control during Acute Hypotension

Developing a reliable method for automated drug infusion systems would improve a patient’s individualized drug therapy under the unexpected and acute changes of hemodynamics in a clinical setting. Automated drug infusion systems for controlling mean arterial blood pressure (MAP) have been previously constructed using proportional-integral-derivative (PID) algorithms [2-3]. As long as the MAP response to pharmacological intervention does not change markedly, the simple PID controls work reasonably well. However, the conventional PID controller might not be able to achieve maximum performance because of the unexpected change of the intraand inter-patient variability. The robustness in the fuzzy PID control and the conventional PID control was tested under the unknown MAP responses to a vasopressor agent (norepinephrine; NE) during acute hypotension.